supported for example by Art Studio

 Because of I/O address clashes, the AMS Mouse does not work
    with SamRam or an M.G.T. interface enabled.  Also, since the AMS
    interface must be initialized, and the state of the AMS interface is
    not saved in the .Z80 snapshot file, it may be necessary to make the
    snapshot before the point at which the Spectrum program initializes the
    AMS interface.  The program Art Studio re-initializes the AMS interface
    regularly, however, so with this program you don't have to worry about
    it.